Blar i forfatter "Brazzini, Gabriele"

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    • Diagnostic Value of JC Polyomavirus Viruria, Viremia, Serostatus and microRNA Expression in Multiple Sclerosis Patients Undergoing Immunosuppressive Treatment 

      Prezioso, Carla; Ciotti, Marco; Brazzini, Gabriele; Piacentini, Francesca; Passerini, Sara; Grimaldi, Alfonso; Landi, Doriana; Nicoletti, Carolina Gabri; Zingaropoli, Maria Antonella; Iannetta, Marco; Altieri, Marta; Conte, Antonella; Limongi, Dolores; Marfia, Girolama Alessandra; Ciardi, Maria Rosa; Mastroianni, Claudio Maria; Palamara, Anna Teresa; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Markers of JC polyomavirus (JCPyV) activity can be used to evaluate the risk of progressive multifocal leukoencephalopathy (PML) in treated multiple sclerosis (MS) patients. The presence of JCPyV DNA and microRNA (miR-J1-5p), the anti-JCV index and the sequence of the non-coding control region (NCCR) in urine and plasma were determined in 42 MS subjects before treatment (T0), 6 months (T6) and ...

    • High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis 

      Bitossi, Camilla; Viscido, Agnese; Prezioso, Carla; Brazzini, Gabriele; Trancassini, Maria; Borrazzo, Cristian; Passerini, Sara; Frasca, Federica; Scordio, Mirko; Sorrentino, Leonardo; Oliveto, Giuseppe; Fracella, Matteo; D'Auria, Alessandra; Selvaggi, Carla; Cimino, Giuseppe; Midulla, Fabio; Pierangeli, Alessandra; Antonelli, Guido; Moens, Ugo Lionel; Pietropaolo, Valeria; Scagnolari, Carolina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were ...

    • KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients 

      Prezioso, Carla; Moens, Ugo; Oliveto, Giuseppe; Brazzini, Gabriele; Piacentini, Francesca; Frasca, Federica; Viscido, Agnese; Scordio, Mirko; Guerrizio, Giuliana; Rodio, Donatella Maria; Pierangeli, Alessandra; d'Ettorre, Gabriella; Turriziani, Ombretta; Antonelli, Guido; Scagnolari, Carolina; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 ...

    • Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens 

      Prezioso, Carla; Brazzini, Gabriele; Passerini, Sara; Di Fabio, Carlotta; Cosio, Terenzio; Bernardini, Sergio; Campione, Elena; Moens, Ugo; Pietropaolo, Valeria; Ciotti, Marco (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
      To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS). In the search for a possible role for ...